Ryan J. Arsenault

Education

  • Postdoctoral Research Scientist, United States Department of Agriculture, Agricultural Research Service, College Station, Texas, 2012-2015
  • Ph.D. (Biochemistry) – Vaccine and Infectious Disease Organization / Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada, 2012
  • Honours B.Sc. (Biochemistry) – Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada, 2006

Research Interests

  • Animal biology from a kinome perspective. Cellular signal transduction is central to almost all physiological functions and kinase enzymes regulate this signaling. Through the use of a novel, high-throughput technology and bioinformatics techniques the kinome can be studied under a variety of conditions.
  • Gut health. The gastrointestinal system is important to many aspects of animal biology, be it health, performance, disease susceptibility, metabolism, stress, etc. The gut microbiome is an important component of both gut health and animal biology. Studying the function and dysfunction of the gut, at the molecular, cellular and tissue level provides valuable biological insight.
  • Immuno-metabolism and disease pathogenesis. Current disease research tends to focus solely on the immune response to infection and pathogenesis. However, the immune system has extensive interactions with host metabolism, and pathogens often target host metabolic machinery. The study of disease from an immuno-metabolism perspective broadens the view of disease pathogenesis and potential intervention strategies. In food animals infectious disease is both a food safety and a zoonotic concern, thus interventions in the live animal can significantly impact human health.

Professional Activities

  • Associate Editor – Frontiers in Veterinary Infectious Disease
  • Editor – Frontiers Special Research Topic “Gut Health: The New Paradigm in Animal Production”
  • Co-Organizer – Annual Symposium on Gut Health in the Production of Food Animals

Select Publications

Napper, S. Dadgar, S., Arsenault, R.J., Trost, B., Scruten, E., Kusalik, A., and Shand, P. Induction of Tissue- and Stressor-Specific Kinomic Responses in Chickens Exposed to Hot and Cold Stresses. Poultry Science. 2015. doi:10.3382/ps/pev046

Arsenault, R.J., Trost, B., and Kogut, M.H. A comparison of the chicken and turkey proteomes and phosphoproteomes in the development of poultry-specific immuno-metabolism kinome peptide arrays. Frontiers in Veterinary Science. 2014. 1:22, doi: 10.3389/fvets.2014.00022

Kogut, M.H., Swaggerty, C.L., Chiang, H.I., Genovese, K.J., He, H., Zhou, H., and Arsenault, R.J. Critical role of glycogen synthase kinase-3β in regulating the avian heterophil response to Salmonella enterica serovar Enteritidis. Frontiers in Veterinary Science. 2014. 1:18, doi: 10.3389/fvets.2014.00010.

Kindrachuk, J., Wahl-Jensen, V., Safronetz, D., Trost, B., Hoenen, T., Arsenault, R., Feldmann, F., Traynor, D., Postnikova, E., Kusalik, A., Napper, S., Blaney, J., Feldmann, H., and Jahrling, P. Ebola Virus Modulates Transforming Growth Factor-β Signaling and Cellular Markers of Mesenchymal-Like Transition in Hepatocytes. 2014. Journal of Virology. 2014, 88(17), 9877-9892.

Arsenault, R.J., Kogut, M.H., and He, H. Combined CpG and Poly I:C Stimulation of Monoctyes Results in Unique Signaling Activation Not Observed with the Individual Ligands. Cellular Signalling. 2013, 25, 2246–2254.

Arsenault, R.J., Napper, S., Kogut, M.H. Salmonella enterica Typhimurium Infection Causes Metabolic Changes in Chicken Muscle involving AMPK, Fatty Acid and Insulin/mTOR Signaling. Veterinary Research. 2013, 44(35).

Trost, B., Arsenault, R., Griebel, P., Napper, S., and Kusalik, A. DAPPLE: A pipeline for the homology-based prediction of phosphorylation sites. Bioinformatics. 2013, 29(13), 1693-1695.  

Arsenault, R.J., Li, Y., Maattanena, P., Scruten, E., Doig, K., Potter, A., Griebel, P., Kusalik, A., and Scott Napper. Altered Toll-Like Receptor 9 Signaling in Mycobacterium avium subsp. paratuberculosis-Infected Bovine Monocytes Reveals Potential Therapeutic Targets. Infection and Immunity. 2013, 81(1), 226-237

Arsenault, R.J., Li, Y., Potter, A., Griebel, P.J., Kusalik, A., Napper, S. Induction of Ligand-Specific PrPC Signaling in Human Neuronal Cells. Prion, 2012, 6(5).

Arsenault, R.J., Li, Y., Bell, K., Doig, K., Potter, A., Griebel, P.J., Kusalik, A., and Napper, S. Mycobacterium avium subsp. paratuberculosis inhibits interferon gamma-induced signaling in bovine monocytes: Insights into the cellular mechanisms of Johne’s Disease. Infection and Immunity. 2012, 80(9), 3039-3048.

Li, Y., Arsenault, R.J., Trost, B., Slind, J., Griebel, P.J., Napper, S., and Kusalik., A. A systematic approach for analysis of peptide array kinome data. Science Signaling. 2012, 5, pl2.

Kindrachuk, J., Arsenault, R., Kusalik, T., Kindrachuk, K.N., Trost, B., Napper, S., Jahrling, P.B., and Blaney, J.E. Systems kinomics demonstrates congo basin monkeypox virus infection selectively modulates host cell signaling responses as compared to West African monkeypox virus. Molecular and Cellular Proteomics. 2011, 11(6), mcp.M111.015701.

Arsenault, R.J., Jalal, S., Babiuk, L.A., Potter, A., Griebel, P.J., and Napper, S. Kinome analysis of Toll-like receptor signaling in bovine monocytes. Journal of Receptors and Signal Transduction. 2009, 29(6), Pg 299-311.

Jalal, S., Arsenault, R., Potter, A.A., Babiuk, L.A, Griebel, P.J., and Napper, S. Genome to Kinome: Species-Specific Peptide Arrays for Kinome Analysis. Science Signaling 2009, 2(54), pl1.

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Contact Information
Ryan J. Arsenault

Assistant Professor

Animal and Food Sciences
022 Townsend Hall

Newark, DE 19716
Phone: (302) 831-7579

Email: rja@udel.edu