Larry A. Cogburn, Ph.D.

Education

  • Environmental Physiology, University of Illinois, Urbana-Champaign, Ph.D. 1978
  • Physiology, North Carolina State University, Raleigh, M.Sc., 1974
  • Poultry Science, North Carolina State University, Raleigh, B.S., 1972

Current Courses

  • ANFS 445, Comparative Physiology of Domestic Animals
  • UNIV 401/402; Research Advisor and Sponsor, Degree with Distinction and Honors Degree with Distinction

Major Federal Grants

  • USDA-NRI Grant 2005-35206-15288.  Integrated Analysis of Gene Networks Controlling Feed Intake and Energy Metabolism in Chickens. L.A. Cogburn and T.E. Porter, Co-PD
  • USDA-IFAFS Grant 00-52100-9614: A Consortium for Functional Mapping of Growth-Regulating Genes in Broiler Chickens.  L.A. Cogburn (PD), T.E. Porter, J. Simon, and S.E. Aggrey, Co-PIs

Research Interests 

  • Molecular Endocrinology
  • Avian Functional Genomics
  • Avian Systems Biology
  • Gene Network Modeling
  • Development of Molecular Markers for Genetic Selection
  • Molecular and Genetic Mechanism of Obesity and Type II Diabetes
  • Comparative and Evolutionary Genomics
  • Integrative Genomics
  • Avian Systems Biology
Professional Activities

  • The Endocrine Society
  • American Physiological Society
  • Poultry Science Association
  • Sigma Xi
  • American Association of University Professors

Patents

  • Cogburn, L. A., Identification of Fat and Lean Phenotypes in Chickens using Molecular Markers, U.S. Patent # US 7,666,590 B2, Date of Patent: February 23, 2010.
  • Cogburn, L. A., Molecular Markers for Identification of Fat and Lean Phenotypes in Chickens, U.S. Patent Application, Serial No. 60/359,846 filed February 27, 2003. [Pub. No.: US 2003/0186299 A1; Pub. Date: Oct. 2, 2003]
  • Cogburn, L. A., Molecular Markers for Identification of Fat and Lean Phenotypes in Chickens, U.S. Patent Application, Serial No. 11/013,536 filed December 12, 2003. [Pub. No.: US 2005/0214814 A1; Pub. Date: Sep. 29, 2005]
  • Cogburn, L. A., Methods For Predicting Fat and Lean Phenotypes in Chickens, United States Patent Application Number 13/008,466, filed January 18, 2011

List of Peer-reviewed Publications (2014-2006)

Friedman-Einat, M., L. A. Cogburn, S. Yosefi, G. Hen, D. Shinder, A. Shirak, and E. Seroussi, 2014. Discovery and characterization of the first genuine avian leptin gene in the rock dove (Columba livia). Endocrinology (Early Release online). (PDF)

Prokop, J.W., Schmidt, C., Gasper, D., Duff, R.J., Milsted, A., Ohkubo, T., Ball, H.C., Shawkey, M.D., Mays, Jr., H.L., Cogburn, L.A., and Londraville, R.L., 2014. Discovery of the elusive leptin in birds: Identification of several ‘missing links’ in the evolution of leptin and its receptor. PLOS One 9(3):e92751. (PDF)

Demeure O, Duclos M, Bacciu N, Le Mignon G, Filangi O, Pitel F, Boland A, Lagarrigue S, Cogburn LA, Simon J, Le Roy P, Le Bihan-Duval E, 2013. Genome-wide interval mapping using SNPs identifies new QTL for growth, body composition and several physiological variables in an F2 intercross between fat and lean chicken lines. Genet Sel Evol 45: 36. 10.1186/1297-9686-45-36.

Resnyk CW, Carré W, Wang X, LeBihan-Duval E, Duclos MJ, Simon J, Aggrey SE, Porter TE, Cogburn LA, 2013. Transcriptional analysis of abdominal fat in genetically fat and lean chickens reveals adipokines, lipogenic genes and a link between hemostasis and leanness. BMC Genomics 14: 557.

Jenkins S, Ellestad L, Mukherjee M, Narayana J, Cogburn LA, Porter TE, 2013. Glucocorticoid-induced changes in gene expression in embryonic anterior pituitary cells. Physiol. Genomics, 45:422-433.

Simon J, Milenkovic D, Godet E, Cabau C, Collin A, Metayer-Coustard S, Rideau N, Tesseraud S, Derouet M, Crochet S, Cailleau-Audouin E, Hennequet-Antier C, Gespach C, Porter TE, Duclos MJ, Dupont J and Cogburn LA, 2012. Insulin immuno-neutralization in fed chickens: Effects on liver and muscle transcriptome. Physiol Genomics 44: 283-292.

Le Bihan-Duval E., Nadaf J., Berri C., Pitel F., Graulet B., Godet E., Leroux S.Y., Demeure O., Lagarrigue S, Duby C, Cogburn L.A., Beaumont C.M., Duclos M.J., 2011: Detection of a cis eQTL controlling BCMO1 gene expression leads to the identification of a QTG for chicken breast meat color. Plos One, 6:e14825.

Byerly MS, Simon J, Cogburn LA, Le Bihan-Duval E, Duclos MJ, Aggrey SE, Porter TE, 2010. Transcriptional profiling of the hypothalamus during development of adiposity in genetically selected fat and lean chickens. Physiol Genomics. 42(2):157-67.

Higgins, S.E., L.E. Ellestad, N. Trakooljul, L.A. Cogburn, F. McCarthy, J. Saliba and T.E. Porter, 2010. Global gene expression and pathway analysis in the hypothalamus of neonatal chicks during feeding, fasting and delayed feeding. BMC Genomics 11:162.

Jonchere, V., S. Réhault-Godbert, C. Hennequet-Antier, C. Cabau, V. Sibut, L. A. Cogburn, Y. Nys  and J. Gautron, 2010. Gene expression profiling to identify eggshell proteins involved in physical defense of the chicken egg. BMC Genomics 11:57.

Ankra-Badu, G.A., Le Bihan-Duval, E., Mignon-Grasteau, S., Pitel, F., Beaumont, C., Duclos, M.J., Simon, J., Carre, W., Porter, T.E., Vignal, A., Cogburn, L.A, Aggrey, S.E., 2009. Mapping QTL for growth and shank traits in chickens divergently selected for high or low body weight.  Animal Genetics 41(4):400-5.

Ankra-Badu, G. A.,  D. Shriner, E. Le Bihan-Duval, S. Mignon-Grasteau, F. Pitel, C. Beaumont, M.J. Duclos, J. Simon, T.E. Porter, A. Vignal, L. A. Cogburn, D. B. Allison, N. Yi and S. E. Aggrey, 2010. Mapping main, epistatic and sex-specific QTL for body composition in a chicken population divergently selected for low or high growth rate. BMC Genomics 11:107.

Wang,  X., R.F. Newkirk, W. Carre, P. Ghose, B. Igobudia, J.G. Townsel , L.A. Cogburn, 2009. Regulation of ANKRD9 expression by lipid metabolic perturbations.  BMB Reports 42:568-573.

Nadaf, J., F. Pitel, H. Gilbert, M.J. Duclos, F Vignoles, C. Beaumont, A. Vignal, S. E. Aggrey, T.E. Porter, L.A. Cogburn, J. Simon and E. Le Bihan-Duval, 2009. QTL for several metabolic traits map to loci controlling growth and body composition in a F2 intercross between high-growth and low-growth chicken lines. Physiol. Genomics 38:241-249.

Le Mignon, G., F. Pitel, H. Gilbert, E. Le Bihan-Duval, F. Vignoles, O. Demeure,

S. Lagarrigue, J. Simon, L. A. Cogburn, S. E. Aggrey, M. Douaire and P. Le Roy, 2009. A comprehensive analysis of QTL for abdominal fat and breast muscle weights on chicken chromosome 5 using a multivariate approach.  Animal Genetics 40:157-164.

Byerly, M. S., J. Simon, E. Lebihan-Duval, M. J. Duclos, L A. Cogburn and T. E. Porter, 2009. Effects of BDNF, T3 and corticosterone on expression of the hypothalamic obesity gene network in vivo and in vitro. AJP-Regulatory, Integrative and Comparative Physiology 296:R1180-1189.

Dupont J, Tesseraud S, Derouet M, Collin A, Rideau N, Crochet S, Godet E, Cailleau-Audouin E, Metayer-Coustard S, Duclos MJ, Gespach C, Porter TE, Cogburn LA, and Simon J, 2008. Insulin immuno-neutralization in chicken: effects on insulin signaling and gene expression in liver and muscle. J Endocrnol 2008, 197:531-542.

Cogburn, L. A., T. E. Porter, M.J. Duclos, J. Simon, S. C.Burgess, J.J. Zhu, H.H. Cheng, J. B. Dodgson and J. Burnside, 2007. Functional genomics of the chicken—a model organism. Poultry Sci. 86:2059-2094

Nadaf, J., H. Gilbert, F. Pitel, C. Beaumont, C. M. Berri, M. J. Duclos, T.E. Porter, J. Simon, S. E. Aggrey, L. A. Cogburn, E. Le Bihan-Duval, 2007. Identification of QTL controlling several meat parameters in a F2 cross between two chicken lines selected for either low or high growth. BMC Genomics 8:155.

Wang, X., W. Carré, A. M. Saxton and Cogburn, L.A., 2007. Manipulation of thyroid status and/or GH Injection alters hepatic gene expression in the juvenile chicken. Cytogenet. Genome Res. 117:174-188.

Dichlberger, A., L. A. Cogburn, J. Nimpf, and W. J. Schneider. 2007. Avian apolipoprotein A-V binds to LDL receptor gene family members. J. Lipid Res. 48:1451-1456.

Walzem, R. L., R. A. Baillie, M. Wiest, R. Davis, S. M. Watkins, J. Simon, T. E. Porter, and L. A. Cogburn. 2007. Functional annotation of genomic data with metabolic inference. Poult. Sci. 86:1510-1522.

Carre, W., X. Wang, T. E. Porter, Y. Nys, J-S Tang, E. Bernberg, R. Morgan , J. Burnside, S.E. Aggrey, J. Simon, and Cogburn, L. A., 2006. Chicken functional genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index. Physiol. Genomics 25:514-524

Ellestad, L.E., W Carre, M. Muchow, S.A. Jenkin, X. Wang, L.A. Cogburn, and T.E. Porter, 2006. Gene expression profiling during cellular differentiation in the embryonic pituitary gland using cDNA microarrays. Physiol Genomics 25:414-425

Lagarrigue, S., F. Pitel, W. Carré, B. Abasht, P. Le Roy, A. Neau, Y. Amigues, M. Sourdioux, J. Simon, L.A. Cogburn, S. Aggrey, B. Leclerq, A. Vignal and M. Douaire, 2006. Mapping of quantitative trait loci affecting fatness and breast muscle weight in experimental meat-type chicken lines divergently selected on fatness Genet. Select. Evol. 38: 85-97

Abasht, B., Pitel, F., Lagarrigue, S., Le Bihan-Duval, E., Le Roy, P., Demeure, O., Simon J., Cogburn, L. A., Aggrey, S.E., Vignal, A. and Douaire, M. 2005. Fatness QTL on chicken chromosome 5 and interaction with sex. Genet. Select. Evol. 38:297-311

Wang, X., W. Carre, L. Rejto and L. A. Cogburn, 2005. Chapter 3. Transcriptional Profiling in Liver of Hormonally-manipulated Chickens. In: Functional Avian Endocrinology (A Dawson & PJ Sharp, Eds) Narosa Publishing House, New Delhi, India, pp 27-44

Burnside, J. L.A. Cogburn, R. Talbot and J.B. Dodgson. 2005. Chapter 1. Genomic Tools for Endocrine Research. In: Functional Avian Endocrinology (A Dawson & PJ Sharp, Eds), Narosa Publishing House, New Delhi, India, pp 3-10.

Pending Publications

Resnyk, C.W., C. Chen, H. Huang, C.H. Wu, E. Le Bihan-Duval, M. J. Duclos, J. Simon and L. A. Cogburn, 2013. RNA-seq analysis of abdominal fat in genetically fat and lean chickens shows divergent ectopic expression of multiple hemostatic and endocrine factors controlling lipid metabolism (submitted to PLOS One).

Du J, Hinkes MT, Hennequet-Antier C, Brionne A, Cogburn LA, Nys Y, Gautron J, 2013. Identifying specific proteins involved in eggshell membrane formation using transcriptional  and bioinformatic analyses. BMC Genomics (submitted)

Resnyk CW, Carré W, Wang X, Porter TE, Simon J, Le Bihan-Duval E, Duclos MJ, Cogburn LA, 2013. Transcriptional analysis of abdominal fat in chickens selected on body weight identifies novel mechanisms controlling leanness and validates visceral fat as an important lipogenic and endocrine tissue. BMC Genomics (under revision)

Cogburn LA, 2013. Systems Biology of Avian Growth and Development. In: Colin G.Scanes, editor. Sturkie's Avian Physiology. Elsevier.

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Contact Information
Larry A. Cogburn, Ph.D.

Professor of Functional Genomics,
Avian Systems Biology and
Avian Molecular Endocrinology

Animal and Food Sciences
036 Townsend Hall

Newark, DE 19716
Phone: (302) 831-2523
Fax number: (302) 831-2822
Email: cogburn@udel.edu