- Ph.D. ,Biochemistry and Molecular Biology, State University of New York at Stony Brook, 1985
- B.S., Biology, Purdue University, 1979
- Research in our lab focuses on post-transcriptional mechanisms that regulate the expression of genes in higher plants. In particular, we are interested in the fate of mRNA molecules because of their pivotal role as intermediates in the gene expression process. Messenger RNAs are transcribed from genes as precursors that are subsequently processed and exported from the nucleus. In the cytoplasm, the mature mRNAs are bound by ribosomes and direct the synthesis of proteins until they are degraded by ribonucleases. In contrast to transcriptional control mechanisms, the mechanisms that control mRNA stability are poorly understood. The plant system is attractive for the study of mRNA stability because it is amenable to combined molecular, biochemical, and genetic approaches.
Schmidt, S.A.,* Foley, P.L.,* Jeong, D.-H., Rymarquis, L.A., Doyle, F., Tenenbaum, S.A., Belasco, J.G.,# Green, P.J.# Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells. Nucleic Acids Res., 43: 309-23 (2015). Epub 2014 Nov 27. *joint first authors. # joint corresponding authors http://nar.oxfordjournals.org/content/43/1/309.long
Suzuki, Y., Arae, T., Green, P,J., Yamaguchi, J. and Chiba, Y. AtCCR4a and AtCCR4b are involved in determining the poly(A) length of Granule-bound starch synthase 1 transcript and modulating sucrose and starch metabolism in Arabidopsis thaliana. Plant Cell Physiol. Epub 2015 Jan 27. http://pcp.oxfordjournals.org/content/early/2015/03/02/pcp.pcv012.long
Merret, R., Nagarajan, V.K.,^ Carpentier, M-C.,^ Park, S., Favory, J-J., Descombin, J., Picart, C., Charng, Y-y., Green, P.J., Deragon, J.-M., and Bousquet-Antonelli, C. Heat-induced ribosome pausing triggers mRNA co-translational decay in Arabidopsis thaliana. Nucleic Acids Res. (2015). Epub 2015 April 6. ^joint second authors, http://nar.oxfordjournals.org/content/early/2015/04/06/nar.gkv234.long