• UD Search

Mark S. Parcells, Ph.D.

Education

  • University of Delaware, PhD (Biological Sciences), 1994
  • University of Delaware, BA (Biological Sciences), 1984

Current Courses

  • ANFS265, Perspectives in Careers in Animal and Food Sciences
  • ANFS332, Introduction to Animal Diseases (on years when Dr. Keeler is not teaching)
  • ANFS 435/635, Animal Virology
  • ANFS436/636, Immunology of Domestic Animals (to be taught with Dr. Keeler starting Fall 2017)
  • ANFS671, Paradigms in Cell Signaling
  • UNIV101 – First Year Experience: Thinking for yourself: Becoming who you will be, intentionally

Basic Research

Dr. Parcells studies the function of genes encoded by Marek’s Disease Virus (MDV), a T-lymphoma-inducing herpesvirus of chickens.  The projects in his laboratory range from the functional interactions of viral and cellular proteins as they relate to MDV infection and pathogenesis, the evolution of MDV virulence, to the development and testing of vaccines for Marek’s disease.  Dr. Parcells has a strong interest in tumor immunology and tumor virology and vaccine development.

Industry-supported Research

Dr. Parcells works with Poultry and Animal Health Companies to develop and test new vaccines, perform basic mechanism of action studies, and provide expertise in product development and testing.

Research Support

Phaedra Tavlarides-Hontz, Research Associate II

Current Graduate Students and Projects

Sabarinath Neerukonda (Ph.D. student, ANFS)
Role of Exosomes in Marek’s disease virus (MDV) Immunosuppression and Vaccine Responses

Nirajan Bhandari (M.S. student, ANFS)
Role of Mutations in the Oncoprotein of MDV, Meq, in the Evolution of Virulence

Nicholas Egan (M.S. student, BISC)
Role of the Polycomb Repression Complex Protein Bmi-1 in MDV Oncogenicity

Visiting Scholars and Projects

Ying Huang (Visiting Ph.D. Scholar)
Protein-Protein Interactions of MDV Meq proteins Polycomb Protein Complex Proteins Bmi-1 and EZH2

Chuan Lu, Ph.D. (Visiting Scholar)
Role of Polycomb Repression Proteins EED and RBBP7 on MDV Oncogenicity

Undergraduate Students and Projects

Lakshmi Sastry, ANFS Senior
Construction and Characterization of Recombinant Zika Viruses

Kenneth Elliot, ANFS Senior
Role of MDV Meq and RLORF4 Splice Variants on MDV Oncogenicity

Recent Research Publications:

Book Chapters:

Parcells Mark S., Burgess, Shane C. Kaiser HansE, Nasir A, editors. New York, NY, United States: Springer-Verlag New York, Inc.; 2008. Selected Aspects of Cancer Progression: Chapter 11, Immunological aspects of Marek’s disease virus (MDV)-induced lymphoma progression; p.169-191. 250 pages.

 Parcells Mark S., Burnside, Joan, Morgan, Robin W. Robertson ErleS, editor. New York, NY, United States: Springer; 2012. Cancer Associated Viruses: Chapter 13, Marek’s disease virus-induced T-cell lymphomas; p.307-335. 866 pages.

 Research

  • Dr. Parcells studies the function of genes encoded by Marek’s Disease Virus (MDV), a T-lymphoma-inducing herpesvirus of chickens.  The projects in his laboratory range from the generation of infectious clones of MDV and Infectious Laryngotracheitis Virus (ILTV), the functional interactions of viral and cellular proteins as they relate to MDV infection and pathogenesis, the evolution of MDV virulence, to the development and testing of vaccines for Marek’s disease.  Dr. Parcells has a strong interest in tumor immunology and tumor virology and has a current project developing an anti-tumor vaccine for canine hemangiosarcoma.

 

Recent Publications

Morgan R, Anderson A, Bernberg E, Kamboj S, Huang E, Lagasse G, Isaacs G, Parcells M, Meyers BC, Green PJ, Burnside J. Sequence conservation and differential expression of Marek’s disease virus microRNAs. Journal of Virology. 2008; 82(24):12213-20.

Tavlarides-Hontz P, Kumar PM, Amortegui JR, Osterrieder N, Parcells MS. A deletion within glycoprotein L of Marek’s disease virus (MDV) field isolates correlates with a decrease in bivalent MDV vaccine efficacy in contact-exposed chickens. Avian Diseases. 2009; 53(2):287-96

Arumugaswami V, Kumar PM, Konjufca V, Dienglewicz RL, Reddy SM, Parcells MS. Latency of Marek’s disease virus (MDV) in a reticuloendotheliosis virus-transformed T-cell line. II: expression of the latent MDV genome. Avian Diseases. 2009; 53(2):156-65.

Arumugaswami V, Kumar PM, Konjufca V, Dienglewicz RL, Reddy SM, Parcells MS. Latency of Marek’s disease virus (MDV) in a reticuloendotheliosis virus-transformed T-cell line. I: uptake and structure of the latent MDV genome. Avian Diseases. 2009; 53(2):149-55

McCarthy FM, Mahony TJ, Parcells MS, Burgess SC. Understanding animal viruses using the Gene Ontology. Trends in Microbiology. 2009; 17(7):328-35.

Lee SH, Lillehoj HS, Jang SI, Baldwin C, Tompkins D, Wagner B, Parcells M, Del Cacho E, Hong YH, Min W, Lillehoj EP. Development and characterization of mouse monoclonal antibodies reactive with chicken interleukin-2 receptor αlpha chain (CD25). Veterinary immunology and Immunopathology. 2011; 144(3-4):396-404.

Farkas T, Fey B, Hargitt E 3rd, Parcells M, Ladman B, Murgia M, Saif Y. Molecular detection of novel picornaviruses in chickens and turkeys. Virus genes. 2012; 44(2):262-72.

Kumar P, Dong H, Lenihan D, Gaddamanugu S, Katneni U, Shaikh S, Tavlarides-Hontz P, Reddy SM, Peters W, Parcells MS. Selection of a recombinant Marek’s disease virus in vivo through expression of the Marek’s EcoRI-Q (Meq)-encoded oncoprotein: characterization of an rMd5-based mutant expressing the Meq of strain RB-1B. Avian Diseases. 2012; 56(2):328-40.

Shaikh SA, Katneni UK, Dong H, Gaddamanugu S, Tavlarides-Hontz P, Jarosinski KW, Osterrieder N, Parcells MS. A deletion in the glycoprotein L (gL) gene of U.S. Marek’s disease virus (MDV) field strains is insufficient to confer increased pathogenicity to the bacterial artificial chromosome (BAC)-based strain, RB-1B. Avian diseases. 2013; 57(2 Suppl):509-18.

Padhi A, Parcells MS. Positive Selection Drives Rapid Evolution of the meq Oncogene of Marek’s Disease Virus. PloS ONE. 2016; 11(9):e0162180.

Neerukonda SN, Katneni UK, Golovan S, Parcells MS. Evaluation and validation of reference gene stability during Marek’s disease virus (MDV) infection. Journal of Virological methods. 2016;

Anobile, J., V. Arumugaswami, D. Downs, K. Czymmeck, M. S. Parcells and C. J. Schmidt. 2006. Nuclear Localization and Dynamic Properties of the Marek’s Disease Virus Oncogene Products Meq and Meq/vIL8. J. Virool 80:1160-1166.

Trapp, S, Parcells, MS, Kamil, JP, Schumacher, D, Tischer, BK, Kumar, PM, Nair, VK, and Osterrieder, N. 2006. A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis. J. Exp. Med., 203:1307-1317.

Santin, ER, Shamblin, CE, Prigge, JT, Arumugaswami, V, Dienglewicz, RL, and Parcells, MS. 2006. Examination of the effect of a naturally occurring mutation in glycoprotein L on Marek’s disease virus pathogenesis. Avian Dis., 50:96-103.

Anobile, JM, Arumugaswami, V, Downs, D, Czymmek, K, Parcells, MS, and Schmidt, CJ. 2006. Nuclear localization and dynamic properties of the Marek’s disease virus oncogene products Meq and Meq/vIL8. J. Virol., 80(3):1160-6.

Burgess, SC, Young, JR, Baaten, BJG, Hunt, L, Ross, LNJ, Parcells, MS, Kumar, PM, Tragaskes, CA , Lee, LF, and Davison, TF. 2004. Marek’s disease is a natural model for lymphomas overexpressing Hodgkin’s disease antigen (CD30). PNAS USA 101:13879-13884.

Prigge, J. T., V. Majerciak, H. D. Hunt, R. L. Dienglewicz, and M. S. Parcells.  2004.

Construction And Characterization of Marek’s Disease Viruses (MDVs) Having Green

Fluorescent Protein Expression Tied Directly Or Indirectly To Phosphoprotein 38 (pp38)

Expression. Avian Dis.48:471-487. (Received P.P. Levine Award for Best Paper in Avian Diseases, 2004)

Shamblin, C.E., N. Greene, V. Arumugaswami, R. L. Dienglewicz, and M. S. Parcells. 2004. Comparative Analysis of Marek’s Disease Virus (MDV) Glycoprotein-, Lytic Antigen pp38- and Transformation Antigen Meq-encoding Genes: Association of Meq Mutations with MDVs of High Virulence. Vet. Microbiol. 102:147-167.

Picture

Contact Information
Mark S. Parcells, Ph.D.

Professor
Avian Molecular Virology
Co-Interim Director Avian Bioscience Center

Animal and Food Sciences
052 Townsend Hall

Newark, DE 19716
Phone: (302) 831-0114
Fax number: (302) 831-2822
Email: parcells@udel.edu