Carl J. Schmidt, Ph.D.
- Ph.D. Johns Hopkins University, 1986
- B.A. University of Delaware, 1979
- ANSC 300 – Prin. of Animal & Plant Genetics
- ANSC 310 – Animal & Plant Genetics
- ANSC 644 – Bioinformatics
- Herpesviruses are responsible for both substantial human suffering and economic loss. Most members of this class of virus can cause either a lytic or latent infection in host cells. A lytic infection results in death of the host cell while in a latent infection, the herpesvirus genome is maintained within the cell in an intact form. Latently infected cells can be stimulated to reactivate the virus by a variety of means and reactivation yields a release of virus particles. In some cases, latent infection also appears to be responsible for transformation of the host cell to a cancer cell. Our laboratory works on Marek’s disease virus (MDV), a herpesvirus that causes T-cell lymphomas in chickens and Herpesvirus of Turkey (HVT), which can confer resistance to Marek’s disease in chickens. Two major projects are ongoing in the laboratory.
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Schmidt, C.J., M.E. Persia, E. Feierstein, B. Kingham W.W. Saylor (2009). Comparison of a Modern Broiler Line and a Heritage Line Unselected Since the 1950’s. Poultry Science. In press.
Burt, David W, Wilfrid Carrë, Mark Fell, Andy S Law, Parker B Antin, Donna R Maglott, Janet A. Weber, Carl J Schmidt, Shane C Burgess, Fiona M McCarthy (2009) The chicken gene nomenclature committee report. BMC Genomics doi:10.1186/1471‐2164‐10‐S2‐S5.
Schmidt, Carl J., Michael Romanov, Oliver Ryder, Vincent Magrini, Matthew Hickenbotham, Jarret Glasscock, Sean McGrath, Elaine Mardis, and Lincoln D. Stein (2008) Gallus GBrowse: a unified genomic database for the chicken. Nucleic Acids Res. 2008 January; 36(Database issue): D719–D723.
Tudor, Catalina O, Carl J Schmidt, and K Vijay‐Shanker, Mining for Gene‐Related Key Terms: Where Do We Find Them?, Third International Symposium on Semantic Mining in Biomedicine SMBM 2008, Turku Finland, September 2008, 157‐160.
Tudor, Catalina O, K Vijay‐Shanker, and Carl J Schmidt, Mining the Biomedical Literature for Genic Information, BioNLP Workshop in conjunction with ACL‐2008, Columbus Ohio, June 2008, 28‐29.
Anobile, J., Arumugaswami, V., Downs, D., Czymmek, K., Parcells, M., and Schmidt, C.J. (2006) Nuclear Localization and Dynamic Properties of the MarekÕs Disease Virus Oncogene Products Meq and Meq-vIL8.Journal of Virology. 80, 1160-1166.
Karaca, G., Anobile, J., Downs, D., Burnside, J., and Schmidt, C.J. (2004) Herpesvirus of Turkeys: Microarray Analysis of Host Gene Responses to Infection. Virology. 318, 102-111.
Abdel Aouacheria, Michelle Banyai, Dominique Rigal, Carl J. Schmidt and Germain Gillet (2003) Characterization of vNr-13, the first alphaherpesvirus gene of the bcl-2 family, Virology, 316, 256-266
O’Donnell, L.A., Clemmer, J.A., Czymmek, K., and Schmidt, C.J. (2002) Marek’s Disease Virus VP22: Subcellular Localization and Characterization of Carboxyl Terminal Deletion Mutations. Virology 292, 235-240
Kingham, B.F., Zelnik, V., Kopaek, J., Majeriak, V., Ney, E., and Schmidt, C.J. (2001) Genome Sequence of Herpesvirus of Turkeys: Comparative Analysis with Marek’s Disease Viruses. J. Gen Virol. 82, 1123-1135.