Aditya Dutta, Ph.D.


Education and Training:

Associate Research Scientist: Columbia University Irving Medical Center, New York, NY

Postdoctoral Research Scientist: Columbia University Irving Medical Center, New York, NY

Ph.D. (Biology): Syracuse University, Syracuse, NY

M.S. (Biotechnology): Indian Institute of Technology Bombay, Mumbai, India

B.S. with Honors (Biochemistry): University of Delhi, New Delhi, India




Research

Research in the Dutta laboratory is focused on understanding the mechanistic basis of cellular response to oxidative stress in both normal and diseased states. In particular, the laboratory studies mitochondria-mediated mechanisms involved in development and maintenance of reproductive organ systems, in the context of ovarian health and cancer.




Selected Publications:

Le Magnen C, Virk RK, Dutta A, Kim JY, Panja S, Lopez-Bujanda ZA, Califano A, Drake CG,
Mitrofanova A, Abate-Shen C. Cooperation of loss of NKX3.1 and inflammation in prostate
cancer initiation. Disease Models & Mechanisms. 2018 dmm.035139 doi: 10.1242/dmm.035139.

Dutta A, Panja S, Virk RK, Kim JY, Zott R, Cremers S, Golombos, DM, Liu D, Mosquera JM,
Mostaghel EA, Barbieri CE, Mitrofanova A, Abate-Shen C. Co-clinical analysis of a genetically
engineered mouse model and human prostate cancer reveals significance of NKX3.1
expression for response to 5α-reductase inhibition. European Urology. 2017 Oct; 72(4): 499-
506

Dutta A#, Choudhary P#, Caruana J, Raina R. JMJ27, an Arabidopsis H3K9 histone demethylase,
modulates defense against Pseudomonas syringae and flowering time. Plant Journal. 2017
Sep;91(6):1015-1028 (#Equal contribution)

Dutta A#, Le Magnen C#, Mitrofanova A, Ouyang X, Califano A, and Abate-Shen C. Identification
of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate
differentiation. Science. 2016 Jun 24;352(6293):1576-80. (# Equal contribution)

Le Magnen C#, Dutta A#, and Abate-Shen C. Optimizing mouse models for precision cancer
prevention. Nature Reviews Cancer. 2016 Mar;16(3):187-96. (# Equal contribution)

Dutta A, Chan S, Pauli NT, and Raina R. Hypersensitive Response-Like Lesions 1 codes for
Atppt1 and regulates accumulation of ROS and defense against bacterial pathogen
Pseudomonas syringae in Arabidopsis thaliana. Antioxidants & Redox Signaling. 2015 Mar
20;22(9):785-96.

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Contact Information Aditya Dutta, Ph.D.

Assistant Professor

Animal and Food Sciences
050 Townsend Hall
531 S. College Ave
Newark, DE 19716
Phone: (302) 831-4160
Email: adidutta@udel.edu